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当前位置：国际临床研究杂志 > 2022年 6卷 (7)期

Open Access Article

International Journal of Clinical Research. 2022; 6: (7) ; 16-22 ; DOI: 10.12208/j.ijcr.20220297.

Research Progress on the relationship between Intestinal flora and Acute pancreatitis
肠道菌群与急性胰腺炎相关性研究进展

作者： 梁国强, 朱慧, 章一凡 *

南京中医药大学附属苏州市中医医院中心实验室江苏苏州

南京中医药大学附属苏州市中医医院脾胃病科江苏苏州

*通讯作者：章一凡,单位：南京中医药大学附属苏州市中医医院脾胃病科江苏苏州；

苏州市临床重点病种诊疗技术专项江苏省名老中医药专家葛惠男传承工作室建设项目苏州市第九批姑苏卫生重点人才项目

发布时间: 2022-09-07 总浏览量: 863

PDF 全文下载引用本文收录截图（CNKI-Scholar）万方数据（WANFANG DATA）

摘要

急性胰腺炎（AP）是一种常见的胃肠道疾病。大约 15%-20% 的患者发展为严重的 AP。全身炎症反应综合征和多器官功能障碍综合征可能是由于重症AP早期大量释放炎性细胞因子，后期出现肠功能障碍和胰腺坏死。当前研究表明，59%的AP患者伴有肠屏障损伤，肠黏膜通透性增加，导致肠道细菌易位、胰腺组织坏死和感染，并发生多器官功能障碍综合征。关于 AP 的病理生理学、治疗选择和临床试验有相关综述报道。然而，肠道微生物群及其代谢物对 AP 肠道屏障功能的真正影响仍不清楚。本综述总结了AP发展和进展过程中肠道菌群及其代谢物的变化，以揭示AP肠道衰竭的机制。

关键词： 肠道菌群；急性胰腺炎；相关性研究

Abstract

Acute pancreatitis (AP) is a common gastrointestinal disorder. Approximately 15%-20% of patients develop severe AP. Systemic inflammatory response syndrome and multiple organ dysfunction syndrome may be caused by the massive release of inflammatory cytokines in the early stage of severe AP, followed by intestinal dysfunction and pancreatic necrosis in the later stage. Current study showed that 59% of AP patients had associated intestinal barrier injury, with increased intestinal mucosal permeability, leading to intestinal bacterial translocation, pancreatic tissue necrosis and infection, and the occurrence of multiple organ dysfunction syndrome. There are several reviews on the pathophysiology, therapeutic options and clinical trials of AP. However, the real effect of the gut microbiota and its metabolites on intestinal barrier function in AP remains unclear. This review summarizes the alterations in the intestinal flora and its metabolites during AP development and progression to unveil the mechanism of gut failure in AP.

Key words： Intestinal flora; Acute pancreatitis; Correlation study

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引用本文

梁国强, 朱慧, 章一凡, 肠道菌群与急性胰腺炎相关性研究进展[J]. 国际临床研究杂志, 2022; 6: (7) : 16-22.

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