Open Access Article
International Journal of Clinical Research. 2022; 6: (7) ; 10-12 ; DOI: 10.12208/j.ijcr.20220295.
Effect of intravenous infusion time of azithromycin on the treatment effect and safety of children with Mycoplasma pneumoniae pneumonia
阿奇霉素静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响
作者:
刘艳霞 *,
李静
首都医科大学附属北京妇产医院怀柔妇幼保健院 北京
*通讯作者:
刘艳霞,单位:首都医科大学附属北京妇产医院怀柔妇幼保健院 北京;
发布时间: 2022-09-07 总浏览量: 403
PDF 全文下载
引用本文
收录截图(CNKI-Scholar)
万方数据(WANFANG DATA)
摘要
肺炎支原体肺炎主要是指由肺炎支原体感染引起的肺部炎症[1]。流行病学显示该病发病患者年龄偏低,以儿童及青年人居多,常表现为呼吸困难、咳嗽、疲乏、运动耐量下降、发热及头痛等[2]。肺炎支原体肺炎大多症状较轻,但儿童患者由于免疫力低下,呼吸道管腔狭窄,易引发多种并发症如肺不张、心肌损害、肝功损害等,严重影响患儿的生活质量,甚至危及其生命健康,应引起临床重视[3]。目前临床上常早期应用大环内酯类如阿奇霉素通过阻碍肺炎支原体转肽过程抑制其蛋白质合成从而减轻肺炎支原体肺炎患儿症状,缩短病程[4]。但当前多数医护人员对阿奇霉素治疗肺炎支原体肺炎患儿静脉滴注时间尚有异议,为进一步研究阿奇霉素不同静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响,本研究选择180例于本院儿内科治疗的肺炎支原体肺炎患儿作为观察对象,报道如下。
关键词: 肺炎支原体肺炎;阿奇霉素;症状缓解时间;血清学指标CRP含量;不良反应发生率
Abstract
Mycoplasma pneumoniae pneumonia refers primarily to inflammation of the lungs caused by Mycoplasma pneumoniae infection[1]. Epidemiology shows that the onset of the disease is low in age, mostly in children and young people, and often presents with dyspnea, cough, fatigue, decreased exercise tolerance, fever, and headache [2]. Most of the symptoms of Mycoplasma pneumoniae pneumonia are mild, but due to low immunity and narrowing of the respiratory lumen, pediatric patients are prone to a variety of complications such as atelectasis, myocardial damage, liver function damage, etc., which seriously affect the quality of life of children, and even endanger their life and health, which should arouse clinical attention [3]. At present, macrolides such as azithromycin are often used early in clinical practice to inhibit protein synthesis by obstructing the transpeptide process of Mycoplasma pneumoniae, thereby alleviating symptoms and shortening the course of disease in children with Mycoplasma pneumoniae pneumonia [4]. However, at present, most medical staff still have objections to the time of intravenous infusion of azithromycin in children with Mycoplasma pneumoniae pneumonia, in order to further study the effect and safety of different intravenous infusion times of azithromycin on the treatment effect and safety of children with Mycoplasma pneumoniae pneumonia, this study selected 180 cases of children with Mycoplasma pneumoniae treated in the pediatric department of this hospital as observation objects, the report is as follows.
Key words: Mycoplasma pneumoniae pneumonia; Azithromycin; Duration of symptom relief; Serological index CRP content; Incidence of adverse reactions
参考文献 References
[1] 江铭,张丽华,钱小芳.大剂量甲泼尼龙琥珀酸钠联合阿奇霉素治疗RMPP患儿的效果[J].数理医药学杂志,2022, 35(06): 869-871.
[2] 王淑敏,姜之炎,李倩,刘秀秀,张奕星,肖臻.基于网络药理学探讨清肺通络方治疗儿童肺炎支原体肺炎的作用机制[J/OL].世界科学技术-中医药现代化:1-11 [2022-07 -04].http://kns.cnki.net/kcms/detail/11.5699.R.20220608.1745.020.html
[3] 孟昱瑾.喜炎平联合阿奇霉素治疗小儿支原体肺炎的效果[J].中国医药指南,2022,20(14):53-56.
[4]宋瑞,赵庆坤.支气管镜灌洗联合布地奈德局部给药治疗儿童重症肺炎支原体肺炎的效果研究[J].临床医学,2022, 42(05):60-62.
[5] 何玲,余泽豪.重症肺炎支原体肺炎CD3~+HLA-DR表达与VitA水平相关性分析[J].昆明医科大学学报,2022, 43(05):103-107.
[6] 李珊珊,李英会,张瑾.加味麻杏石甘汤联合阿奇霉素治疗痰热闭肺型小儿支原体肺炎的临床研究[J].中国处方药,2022,20(05):135-137.
[7] 王新蓉,王书乐,范炜方,高吟.阿奇霉素加用化痰止咳合剂及止咳贴治疗肺炎支原体肺炎临床价值[J].中国医药科学,2022,12(09):103-106.
[8] 杨金梅.炎琥宁联合阿奇霉素、布地奈德雾化吸入治疗小儿支原体肺炎的临床观察[J].中国民间疗法,2022, 30(09):94-96.
[9] 于欣,刘国凤,陈桂华,冯孝强.布地奈德雾化吸入联合阿奇霉素对肺炎支原体感染患儿的效果[J].西北药学杂志,2022,37(03):153-156.
[10] 严尔锐,赵春阳.阿奇霉素静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响[J].临床合理用药杂志,2020,13(35):18-20.
引用本文
刘艳霞, 李静, 阿奇霉素静脉滴注时间对肺炎支原体肺炎患儿治疗效果及安全性的影响[J]. 国际临床研究杂志, 2022; 6: (7) : 10-12.