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当前位置：国际临床研究杂志 > 2022年 6卷 (7)期

Open Access Article

International Journal of Clinical Research. 2022; 6: (7) ; 4-9 ; DOI: 10.12208/j.ijcr.20220294.

Advances in diagnosis and treatment of adult-onset chronic active EBV infection
成人慢性活动性EB病毒感染诊疗进展

作者： 王龙飞, 邢昊, 张传辉, 张倩, 金珍婧 *

吉林大学第二医院肝胆胰内科吉林长春

*通讯作者：金珍婧,单位：吉林大学第二医院肝胆胰内科吉林长春；

吉林省财政厅卫生专项

发布时间: 2022-09-07 总浏览量: 750

PDF 全文下载引用本文收录截图（CNKI-Scholar）万方数据（WANFANG DATA）

摘要

慢性活动性EB病毒感染（chronic active Epstein–Barr virus infection,CAEBV）是EB病毒阳性T/NK细胞淋巴增值性疾病之一，其特征为EBV感染的T/NK细胞克隆性增殖并浸润全身器官，导致其衰竭。本病发病机制尚不明确，该病往往持续进展，病程中可出现噬血细胞综合征、多脏器功能衰竭、淋巴瘤、机会性感染等危及生命并发症。该病预后差，病死率高，尚无明确治疗方案，异基因造血干细胞移植被证明为唯一有效治疗方法。CAEBV临床少见，好发于儿童及青少年，成人罕见，国内有关成人CAEBV研究较少，本文就成人CAEBV临床特点及诊治进行综述，以提高临床对该病的诊治水平。

关键词： 成人；慢性活动性EB病毒感染；治疗

Abstract

Chronic active EB virus infection is one of EB virus positive T/NK cell lymphoproliferative diseases, characterized by clonal proliferation of EBV-infected T/NK cells and their infiltration into systemic organs, leading to their failure. The pathogenesis of this disease remains unclear, the disease progresses continuously, Life-threatening complications such as hemophagocytic syndrome, multiple organ failure, lymphoma, opportunistic infections may occur during the course of the disease. Chronic active EB virus infection has a poor prognosis and high mortality, allogeneic hematopoietic stem cell transplantation proved to be the only effective treatment. Chronic active EB virus infection is rare in clinic, more likely to occur in children and adolescents, and is rare in adults. There are few domestic studies on adult-onset Chronic active EB virus infection, This article reviews the clinical characteristics, diagnosis and treatment of adult-onset Chronic active EB virus infection, To improve the clinical diagnosis and treatment of the disease.

Key words： Adult; Chronic Active EB Virus Infection; Treatment

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引用本文

王龙飞, 邢昊, 张传辉, 张倩, 金珍婧, 成人慢性活动性EB病毒感染诊疗进展[J]. 国际临床研究杂志, 2022; 6: (7) : 4-9.

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