CSCIED

期刊目次

加入编委

期刊订阅

添加您的邮件地址以接收即将发行期刊数据:

Open Access Article

International Journal of Clinical Research. 2022; 6: (8) ; 180-184 ; DOI: 10.12208/j.ijcr.20220428.

The research progress on the role of melatonin in children with precocious puberty
性早熟儿童褪黑素作用研究进展

作者: 杨祺, 王爱萍 *

昆明市第一人民医院儿童生长发育管理中心 云南昆明

*通讯作者: 王爱萍,单位:昆明市第一人民医院儿童生长发育管理中心 云南昆明;

发布时间: 2022-10-11 总浏览量: 986

摘要

性早熟作为常见的儿童内分泌疾病之一,在全球的发病率呈显著上升趋势。目前普遍认为光周期信号与性早熟的发病有关,这提示我们与光周期信号密切相关的褪黑素对于性早熟的发病可能存在一定的影响作用,然而具体作用及机制尚未被证实。近年来,随着国内外学者对褪黑素相关的动物模型以及人类研究的深入,发现褪黑素对人类的生殖系统、 内分泌系统以及生物节律等方面均存在不同程度的调控作用,并且可能通过影响下丘脑-垂体-性腺轴、下丘脑-垂体-肾上腺轴以及KiSS1基因的表达等方式对性早熟的发病产生影响。但是,目前对于性早熟儿童褪黑素的分析研究较少,本文将对性早熟儿童褪黑素作用的研究进展进行综述。

关键词: 褪黑素;性早熟;儿童

Abstract

As one of the common endocrine diseases in children, precocious puberty has a significant increasing incidence in the world. At present, it is generally believed that photoperiod signals is related to the onset of precocious puberty, which suggests us that melatonin has a probable effect on the onset of precocious puberty, but the specific effectand mechanism have not been confirmed yet. In recent years, with the in-depth studies on melatonin-related animal models and human beings, it has been found that melatonin has different degrees of regulation on human genital system, endocrine system and biological rhythm. In addition, melatonin may affect the onset of precocious puberty by affecting the hypothalamo pituitary gonadal axis , The hypothalamic–pituitary–adrenal axis and KiSS1 gene expression. However, there are few studies on the analysis of melatonin in children with precocious puberty at present. This article will review the research progress on the role of melatonin in children with precocious puberty.

Key words: Melatonin; Precocious puberty; Children

参考文献 References

[1] 性早熟诊疗指南(试行)【卫办医政发(195)号】[J]. 中国儿童保健杂志,2011,19(04):390-392. ISSN:008-6579(2011)04-0390-03

[2] Signe Sloth Mogensen, Lise Aksglaede, Annette Mouritsen, et al. Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty. J Clin Endocrinol Metab, 2011. 96(5): p. 1393-401.doi:10.1210/jc.2010-2745

[3] 陈娴,孙飞,夏克惜,等.嘉兴地区2013—2018年儿童性早熟537例病因分析[J].中国乡村医药,2019,26(21):54-55.doi:10.19542/j.cnki.1006-5180.003368.

[4] 刘毓,江超,杨莹,等.  487例儿童性早熟病因分析[J].重庆医学,2016,45(13):1835-1836.

[5] KVS Hari Kumar, A Verma, Kd Modi, et al.Precocious puberty and pineal cyst--an uncommon association. Indian Pediatr, 2010. 47(2): p. 193-4.doi:10.1007/s13312-010-0034-1

[6] Sankha Bhattacharya, Krishna Kumar Patel, Deepa Dehari, et al.Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem, 2019. 462(1-2): p. 133-155.doi:10.1007/s11010-019-03617-5

[7] Erika Cecon, Lei Liu, Ralf Jockers. Melatonin receptor structures shed new light on melatonin research. J Pineal Res, 2019. 67(4): p. e12606.doi:10.1111/jpi.12606

[8] Ting Gao, Zixu Wang, Yulan Dong, et al.Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice. J Pineal Res, 2019. 67(1): p. e12574.doi:10.1111/jpi.12574

[9] Takashi Yoshimura. Neuroendocrine mechanism of seasonal reproduction in birds and mammals. Anim Sci J, 2010. 81(4): p. 403-10. doi:10.1111/j.1740-0929.2010.00777.x

[10] Sue Binkley, James L.Stephens, Jerome b. Riebman, et al.Regulation of pineal rhythms in chickens: photoperiod and dark-time sensitivity. Gen Comp Endocrinol, 1977. 32(4): p. 411-6. doi:10.1016/0016-6480(77)90222-2

[11] 薛海龙,赵蒙,常彤,等. 光周期调控动物繁殖的信号通路研究进展[J]. 特产研究,2020,42(02):76-78.doi:10.16720/j.cnki.tcyj.2020.02.013.

[12] 张红春,李勇,张岩,等. 褪黑素在动物卵泡发育和闭锁中作用的研究进展[J]. 黑龙江畜牧兽医,2021,(07): 38-43+153-154. doi:10.13881/j.cnki.hljxmsy.2020.08.0353.

[13] S.-J. Wang, W.-J. Liu, C.-J. Wu, et al. Melatonin suppresses apoptosis and stimulates progesterone production by bovine granulosa cells via its receptors (MT1 and MT2). Theriogenology, 2012. 78(7): p. 1517-26. doi:10.1016/j.theriogenology.2012.06.019

[14] Hasan Riaz, Muhammad Rizwan Yousuf, Aixin Liang,et al.Effect of melatonin on regulation of apoptosis and steroidogenesis in cultured buffalo granulosa cells. Anim Sci J, 2019. 90(4): p. 473-480. doi:10.1111/asj.13152

[15] Hira Sajjad Talpura, Tesfaye Workua, Zia ur Rehmana,et al.Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function. Reprod Biol, 2017. 17(4): p. 380-388. doi:10.1016/j.repbio.2017.10.005

[16] Shujuan Wang, Wenju Liu, Xunsheng Pang,et al.The Mechanism of Melatonin and Its Receptor MT2 Involved in the Development of Bovine Granulosa Cells. Int J Mol Sci, 2018. 19(7). doi:10.3390/ijms19072028

[17] Longfei Xiao, Junjie Hu, Liangli Song, et al.Profile of melatonin and its receptors and synthesizing enzymes in cumulus-oocyte complexes of the developing sheep antral follicle-a potential estradiol-mediated mechanism. Reprod Biol Endocrinol, 2019. 17(1): p. 1. doi:10.1186/s12958-018-0446-7

[18] Ya-Mei Hea, Hong-Hui Denga, Mei-Hong Shi,et al.Melatonin modulates the functions of porcine granulosa cells via its membrane receptor MT2 in vitro. Anim Reprod Sci, 2016. 172: p. 164-72. doi:10.1016/j.anireprosci.2016.07.015

[19] Deniz Tuna Edizer, Zehra Dönmez, Mehmet Gül, et al. Effects of Melatonin and Dexamethasone on Facial Nerve Neurorrhaphy. J Int Adv Otol, 2019. 15(1): p. 43-50. doi:10.5152/iao.2018.3273

[20] David J. Kennaway. Melatonin research in mice: a review. Chronobiol Int, 2019. 36(9): p. 1167-1183. doi:10.1080/07420528.2019.1624373

[21] Karthik Dhanabalan, Sibonginkosi Mzezewa, Barbara Huisamen, et al. Mitochondrial Oxidative Phosphorylation Function and Mitophagy in Ischaemic/Reperfused Hearts from Control and High-Fat Diet Rats: Effects of Long-Term Melatonin Treatment. Cardiovasc Drugs Ther, 2020. 34(6): p. 799-811. doi:10.1007/s10557-020-06997-9

[22] Tony M. Plant, Suresh Ramaswamy, Meloni J. DiPietro. Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges. Endocrinology, 2006. 147(2): p. 1007-13. doi:10.1210/en.2005-1261

[23] E. Gutie´rrez-Pascual, A. J. Martı´nez-Fuentes, L. Pinilla, M, et al.Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion. J Neuroendocrinol, 2007. 19(7): p. 521-30. doi:10.1111/j.1365-2826.2007.01558.x

[24] Milena Gurgel Teles, Suzy D.C. Bianco, Vinicius Nahime Brito, et al.A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med, 2008. 358(7): p. 709-15.doi:10.1056/NEJMoa073443

[25] L. G. Silveira, S. D. Noel, A. P. Silveira-Neto, et al. Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab, 2010. 95(5): p. 2276-80. doi:10.1210/jc.2009-2421

[26] Young-Jun Rhie,  Kee-Hyoung Lee, Jung Min Ko, et al. KISS1 gene polymorphisms in Korean girls with central precocious puberty. J Korean Med Sci, 2014. 29(8): p. 1120-5. doi:10.3346/jkms.2014.29.8.1120

[27] Brian J. Prendergast. Internalization of seasonal time. Horm Behav, 2005. 48(5): p. 503-11. doi:10.1016/j.yhbeh.2005.05.013

[28] Alexander S. Kauffman, Donald K Clifton, Robert A. Steine. Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Trends Neurosci, 2007. 30(10): p. 504-11. doi:10.1016/j.tins.2007.08.001

[29] 张强. 黑线仓鼠Kiss-1/GPR54系统在季节性繁殖与光周期调控中的作用[D].曲阜师范大学,2013.

[30] Espigares, F, Rocha, A, Gómez, A, et al. Photoperiod modulates the reproductive axis of European sea bass through regulation of kiss1 and gnrh2 neuronal expression. Gen Comp Endocrinol, 2017. 240: p. 35-45.doi:10.1016/j.ygcen.2016.09.007

引用本文

杨祺, 王爱萍, 性早熟儿童褪黑素作用研究进展[J]. 国际临床研究杂志, 2022; 6: (8) : 180-184.