Open Access Article

International Journal of Clinical Research. 2022; 6: (8) ; 22-27 ; DOI: 10.12208/j.ijcr.20220423.

Research advances of IL-32 in liver disease

作者: 童瑶, 张晓珣, 柴进 *

重庆大学医学院 重庆 ;
陆军军医大学第一附属医院(西南医院)消化内科、全军消化病研究所、胆汁淤积肝病中心、代谢相关性脂肪肝中心 重庆

*通讯作者: 柴进,单位:重庆大学医学院 重庆 ;陆军军医大学第一附属医院(西南医院)消化内科、全军消化病研究所、胆汁淤积肝病中心、代谢相关性脂肪肝中心 重庆;

发布时间: 2022-09-26 总浏览量: 1368


白介素32(Interleukin32, IL-32)是一种新型细胞因子,在不同细胞类型中均有表达,可通过经典的促炎细胞因子信号通路诱导炎症的发生,同时也具有调节抗炎细胞因子和免疫抑制分子产生的作用,参与了炎症、肿瘤、肝脏疾病等多种疾病的发生发展。IL-32不同亚型在多种肝脏疾病中起作用,包括肝炎病毒感染、胆汁淤积性肝病、酒精性或非酒精性肝病和肝细胞癌等。本文介绍了IL-32在肝脏疾病中的研究进展,对其在不同肝病中的生物学功能进行初步探讨,也为不同类型的肝脏疾病发病机制及防治策略的研究提供了新的思路。

关键词: 白介素32;肝脏疾病;炎症


Interleukin32 (IL-32) is a novel cytokine, which is expressed in different kinds of cells. IL-32 can induce inflammation through the classical pro-inflammatory cytokine signaling pathway, and also regulates the production of anti-inflammatory cytokines and immunosuppressive molecules. IL-32 is involved in the occurrence and development of inflammation, tumor and other diseases. Different subtypes of IL-32 play a role in a variety of liver diseases, including hepatitis virus infection, cholestatic liver disease, alcoholic or non-alcoholic liver disease, and hepatocellular carcinoma.  In this paper, the research progress of IL-32 in liver diseases was introduced, and its biological functions in different liver diseases were preliminarily discussed, which also provided new ideas for the study of the pathogenesis and prevention strategies.

Key words: Interleukin 32; Liver disease; Inflammation

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童瑶, 张晓珣, 柴进, 细胞因子IL-32在肝脏疾病中的研究进展[J]. 国际临床研究杂志, 2022; 6: (8) : 22-27.